The advise I have seen is to download the XP driver and install it in compatibility mode.  I don't know anyone personally who has ever gotten that running correctly.  And later versions of Windows 10 may not even allow you to install a driver that is not digitally signed.  I found this thread on the topic:

https://answers.microsoft.com/en-us/windows/forum/windows_10-hardware-winpc/windows-10-does-not-recognize-epson-sylus-pro-7600/a49fc41a-b521-4400-9099-bd2634cf7afb?page=1

Regards,
Mike

I had the same problem. Been running windows 7 with epson stylus pro 7600 for years. Computer died and new machine is Win 10. I nearly gave up but this morning I have a working windows 10 machine communicating very happily with my ancient 7600. Just did a nozzle check via the driver and a test graphic via Qimage.

My 7600 is connected directly to a USB port on my computer.

My windows version is Win 10 pro and if it helps the OS build is 19042.1526.

The driver I am using is the XP 64 driver from the epson website (v5.5e)
After unzipping the driver package, I found the SETUP application file located in the setup folder. Right click on this file, select "properties" and then select the "compatibility tab" .
In the compatibility tab tick the box that says "Run this program in compatibility mode for:" and then select "Windows XP (service pack 2)". I also ticked the "Run this program as an administrator",  click apply and then click OK.

Running the setup program at this point will not work.  Believe me I tried.  It looks like its working and installs 2 completely useless icons in the devices and printers window.

First you need to turn off printer signing enforcement. I did this using the one time "Advanced Boot Menu" method described here:

https://www.thewindowsclub.com/disable-driver-signature-enforcement-windows

Having done that I made sure the printer was connected but not turned on.

I then ran the setup application (as administrator just to be sure!).

Choose whether you want to install a 7600 or 9600

I then received a message that the driver was not signed and chose the option to install anyway.
(This repeated once, possibly twice memory fails me, sorry!)

There is then a prompt to plug in and switch on the printer and after a short while (I thought it was going to be yet another fail!) you should have a working printer driver installed and the printer connected.

Seriously, I was at the point of wondering whether I should scrap windows 10 and hope I could wrestle win 7 onto the new machine or completely scrap the 7600.
Happy days...

I hope this helps someone else still keeping a 7600 or 9600 going..great machines

All the best..Phil

Hi Mike,

My pleasure, I hope it helps someone out.
Re your clogged 7600, mine was in a similar condition when I bought it (for very little ££) about 5 years ago. Poor thing was mouldering in a cold garage and hadn't seen the light of day for a very long time. One or two of the ink tubes were completely blocked. Unhooked these from the print head end, adapted an old cartridge so that I could push warm water through the blocked tubes using a syringe. A new set of refillable ink carts and ink from Colourbest, some magic bullet on the docking station for a few hours followed by a couple of power cleans and perfect printing..all nozzles clear.
Has been working fine ever since...(touching wood frantically)
Like I said, great machines.

All the best
Phil