Large TIFF file 315MB.  Windows 8-64.  3.2GHz. 12GB RAM.  Latest QU version 116.
While trying to load the file into the Editor to darken it a bit, it was slow and not showing/loading the image and this message popped up: "Qimage.exe is not responding" with the option to Shutdown or Wait.
First time I shut it down, did it's file report thing in Windows and closed Qimage.
Second time, same thing with the same file and message popped up again.  I selected "Wait" and the image loaded a few seconds later.
Something to do with large TIFF files maybe?  

I do notice some 
red x checkerboard that fills the entire page that sometimes loads into the first window right pane instead of the image itself.  I drag it again and it appears in it normally.  Odd.
Mack