Yes.  The default location for Qimage application data is in the ProgramData folder which is typically C:\ProgramData\ddisoftware\Qimage.  During installation of Qimage Ultimate, you can change that to go to any drive and folder.  Your C: drive may be an SSD for example and you want the Qimage application data like thumbs, raw cache, and exports from PS/LR/Elements to go to your D: drive so you might set the application data folder to something like D:\Qimage-App-Data during install.  In that example, your images exported from PS/LR/Elements would go to D:\Qimage-App-Data\Plugins\Export.

If Qimage Ultimate is already installed, you can use Utilities, Migrate/Copy Application Data on the main menu in Qimage Ultimate and pick the directory and folder where you'd like to move it.  After moving the application data folder, just close Qimage Ultimate and reinstall your plugins so that the plugin installer can find the new Qimage Ultimate application data folder and re-enable the plugins for the new location.

Regards,
Mike