Just in time  to test QU 2021, a friend bought a few of these wooden frames with places for 5 images all different sizes.
I measured the openings in the frame, and built a layout based on the sizes and the location of the picture openings.
Screen snap 052 shows the templates with sizes and locations to match the holes in the wooden frame. (I had to use borderless to get  enough printable area)  There are 5 frame openings

Snap 053 shows the screen ready to print.

Have a fun try.
Fred

This trick has been around a while, but I forgot about it, and maybe you did too?
It has to do with a very easy way to replace an image in a layout.
You look at your work of art and wonder if image 24 might look better than 22 in that corner.
Simply hold the ALT key down and drag the new replacement on top of the old one.
Nah. Old one was better. ALT Drag old one back.

Fred