Doug,
For the sake of this discussion, I will assume that you are getting the screen that asks if youwant to run a monitor profile  in QU.
This pops open when you installed QU in a new computer, or have a new monitor. Windows runs a default monitor profile. Many of us use a selected monitor profile in QU. Many profile their monitors and use that in QU. Some, use a profile that came with the monitor and place that into the MONITOR profile box in QU. Some use the current sRGB.icc that is in our color folder.
So when QU opens it sees the profiles and asks what you want QU to use for the monitor. I use, let QU use xyz even though Windows is using a default other one. Then everone is happy. It even says something to the effect that QU will ask you every tme unless.....
I dont have the alert handy, but to that effect. See screen snap showing the display monitor in QU
Fred

Rebooted...nothing
Uninstalled...reinstalled...Still nothing

Any suggestions on why this program suddenly stopped working and only shows "Please wait"... in yellow rectangle in middle of my screen?

I have to go to Task Manager to close down.  Task Manager says program is running.  But again, only the yellow rectangle.

Mike,
THAT DID IT!!!  Thank you